C. Peter Downes

← Back to University of Dundee

Inclusion identifies researchers whose recorded research contributions may inform their university’s understanding of its research community. It does not rank individual research quality or establish current employment.

Selected research works

Up to 100 highly cited works; DOI links open the original research. Counts reflect the collected record, not real-time citation totals.

1. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

   1997 · 2,826 citations

2. Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

   1982 · 2,136 citations

3. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

   1983 · 1,953 citations

4. The lipid phosphatase activity of PTEN is critical for its tumor supressor function

   1998 · 1,168 citations

5. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

   2004 · 1,123 citations

6. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

   1988 · 1,016 citations

7. Neural and developmental actions of lithium: A unifying hypothesis

   1989 · 1,014 citations

8. The polyphosphoinositide phosphodiesterase of erythrocyte membranes

   1981 · 610 citations

9. Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

   1983 · 552 citations

10. The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

    1982 · 537 citations

11. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

    2000 · 517 citations

12. The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

    1981 · 514 citations

13. PTEN function: how normal cells control it and tumour cells lose it

    2004 · 451 citations

14. Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands

    1985 · 450 citations

15. A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

    2002 · 446 citations

16. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2

    1999 · 429 citations

17. PTEN: The down side of PI 3-kinase signalling

    2002 · 415 citations

18. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

    1999 · 379 citations

19. Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN

    2001 · 365 citations

20. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

    2002 · 359 citations

21. Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

    1996 · 339 citations

22. Inositol trisphosphates in carbachol-stimulated rat parotid glands

    1984 · 298 citations

23. Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

    1986 · 280 citations

24. Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells

    2001 · 235 citations

25. myo ‐Inositol metabolites as cellular signals

    1990 · 232 citations

← Return to the university profile